WebJan 1, 2024 · Among these, amiodarone-induced pulmonary toxicity (APT) occurs in 4–17% of cases and, if not early diagnosed and treated, may evolve towards pulmonary fibrosis and respiratory failure. A 76 years-old-man went to the hospital for accidental trauma. WebA better understanding of the mechanism of amiodarone pulmonary toxicity will not only improve diagnostic approaches to patients with this serious lung disorder, but will also provide the opportunity to develop unique therapeutic strategies that control the toxicity and potentially not interfere with the intended therapeutic efficacy of the drug.
Amiodarone-induced pulmonary toxicity with an excellent …
WebOct 9, 2016 · It has been implicated that a direct toxic injury to type II pneu-mocytes and lung parenchyma and an indirect immunologic reaction in genetically predisposed patients are the two major mechanisms of action. 5 Different forms of pulmonary disease, including interstitial pneumonitis, organizing pneumonia, acute respiratory distress syndrome, … WebThere have been several suggested mechanisms of APT, but the two most likely hypotheses are cytotoxic effects to type II pneumocytes and lung parenchyma, and an immune-mediated mechanism in genetically predisposed patients ( 8 ). Diagnosis is often one of exclusion as there are no specific laboratory analyses to confirm APT. particle works安装包
Drug-induced pulmonary disorders. Semantic Scholar
WebPULMONARY DISEASES By VISHWANATH GOUDA 1st Year M.Pharm ... Amiodarone induced pulmonary toxicity . 1) BRONCHOSPASM ... MECHANISM OF ACTION Anaphylaxis- IgE mediated Direct airway irritation Precipitating IgG antibodies Cycloxygenase inhibition Pharmacologic effects . WebMay 31, 2012 · The toxic mechanism of amiodarone leads to the disruption of the lysosomal membranes of molecules through protein C activation and the subsequent release of toxic oxygen radicals, which may induce activation of caspase pathways and lead to apoptosis of lung epithelial cells [ 24 ]. WebPulmonary toxicity is the most dangerous event that leads to respiration malfunction or even death. 5, 6 Pulmonary toxicities may happen in acute and subacute/chronic patterns. AMD-induced pulmonary toxicity may evolve as chronic interstitial pneumonitis or mimic pulmonary fibrosis if not early diagnosed and treated. particle unity 2d