Plzf transcription factor
WebSep 19, 2008 · Selective Expression of PLZF in CD1d-Restricted NKT Cells. To identify the transcription factors involved in NKT cell development, we performed a microarray screen … WebApr 1, 2016 · PLZF (Promyelocytic Leukemia Zinc Finger) is a BTB-POZ transcription factor. Two co-orthologs of the human PLZF are found in teleost fish species. Zebrafish Plzf …
Plzf transcription factor
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WebPlzf (Promyelocytic Leukaemia Zinc-Finger) is one of the first transcription factor shown to be required for self-renewal of SSCs [ 7] and is also co-expressed along with Oct-4 in undifferentiated spermatogonia [ 13 ]. Plzf is expressed during embryogenesis and plays a crucial role during limb and axial skeletal patterning. WebJan 9, 2024 · The promyelocytic leukemia zinc finger (PLZF) transcription factor mediates a wide‐range of biological processes. Accordingly, perturbation of PLZF function results in a myriad of physiologic defects, the most conspicuous of which is …
WebDec 16, 2015 · As a transcription factor, PLZF shows tight regulation in its cell-type-specific and stage-specific expression patterns. Emerging evidence shows that PLZF regulates the balance of self-renewal and differentiation … WebSep 23, 2024 · We present evidence that the promyelocytic leukaemia zinc finger (Plzf) transcription factor is required for this transition to happen in an orderly fashion. Plzf expression is high in the early anterior hindbrain, then gradually upregulated posteriorly and confined to neural progenitors.
WebJul 28, 2009 · The PLZF transcription factor is essential for the innate phenotype of NKT cells. This report shows that PLZF is likewise responsible for the innate, NKT-like … WebApr 24, 2024 · Among these are transcription factors (TFs), an important class of proteins that regulate the occurrence, formation, and development of tumors. It is difficult for SMDs and macromolecular drugs to identify bioactive sites in TFs and hence for use as pharmacological inhibitors in targeting TF proteins.
WebFunction [ edit] This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger …
WebJul 30, 2015 · Among a number of transcription factors identified to date, NF-κB still remains the most prominent and studied factor for its diverse range of selective transcriptional activities. ... The transcriptional regulator PLZF is a critical co-factor that limits NF-κB-mediated inflammatory responses by maintaining a transcriptionally … chemists celebrate earth weekWebNov 11, 2024 · PLZF is a transcription factor involved in multiple biological processes such as neurogenesis, spermatogenesis, invariant natural killer T-cell development, and leukemogenesis 25,30,31,32. We would like to show you a description here but the site won’t allow us. flight level aviation amslWebJul 5, 2016 · These findings reveal the multilayered architecture of the transcriptional program recruited by PLZF and elucidate how a single transcription factor can drive the … flightlevel aviation bivWebJan 20, 2024 · Critical transcription factors regulate ILC development.After the stage of common lymphoid progenitor (CLP), transcription factors such as TCF1, TOX and Nfil3, together with the Notch signals, promote the generation of an early innate lymphoid progenitor (EILP) expressing Integrin α 4 β 7.EILP has the potential to become both the … chemists chapeltownWebOct 8, 2013 · PLZF is a member of the BTB/POZ family of transcription factors known to regulate progenitor maintenance in multiple tissues [25]. PLZF was initially identified as a protein whose functions are subverted through chromosomal rearrangements resulting in acute promyelocytic leukemia [26]. flight level aviation bivWebMay 23, 2004 · Zfp145 (also known as Plzf, promyelocytic leukemia zinc-finger) was identified by virtue of its involvement in chromosomal translocations with the gene Rara (retinoic acid receptor-α), which is... flight level aviation dutchessWebDec 21, 2012 · The transcription factor PLZF is responsible for most of these properties, as its ectopic expression in conventional T cells is sufficient to confer to them an NKT-like phenotype. The molecular program downstream of PLZF, however, is largely unexplored. chemists chermside