WebSox2 is known to bend DNA, and examination of protein-induced DNA bending is necessary to gain insight into DNA's structural deformation. As a result of this bending nature, the binding of Sox2 altered the conformation of B-form DNA … Web28. aug 2015 · Our results also demonstrate that S95/98 prevents the cooperative binding of SOX2 and OCT4 on Hoxb1-like motifs, as shown by lack of a supershift of the OCT4/DNA …

SOX2 O-GlcNAcylation alters its protein-protein …

WebThe conserved binding site is shown for OCT4 (red) and SOX2 (bold). A: Bandshift showing a supershift with OCT4 antibody, using NCCIT-derived nuclear extracts and a Cy5 labelled … WebWhen embryonic stem cell pluripotency is achieved, Oct4 switches from the Sox2 to the Sox17 promoter. This switch allows the cells to turn off the pluripotency Oct4-Sox2 loop … lagu hitam putih berlalu

Molecular basis for the genome engagement by Sox proteins

Web10. apr 2024 · In addition, both the 5’ UTR and 3’ UTR of OTUD6B mRNA contained the specific motif for RARα binding (Figure 6M). Using a luciferase reporter containing 5’ UTR and 3’ UTR of OTUD6B (Figure 6M ), we found that ATRA promotes the luciferase translation in a RAR α -dependent manner, confirming it recognizes OTUD6B mRNA and thus … Web4. dec 2024 · We hypothesize that the initial two DNA bends are induced by sequential Sox2 binding to the two high-affinity HMG-TF binding motifs, where each binding induces an apparent 32° bend at the sites of interactions (a net 70° DNA apparent bend angle in the ternary complex). ... Sox2 binding isotherm of the U ⇋ B I transition as probed by ... Web23. apr 2015 · The stable, motif-driven targeting by Sox2 on nucleosomes in the ChIP-seq data show much lower co-binding with Oct4 (Soufi et al., 2012) than seen in live imaging (Chen et al., 2014), leaving open whether the latter approach depicts nucleosomal or free DNA binding during genome scanning. lagu hip hop indonesia tahun 2000an